Drug mechanism of action

Lozenges for the treatment of sore throat provide relief of discomfort in cases of oral inflammation.



This effect has not been fully explained so far.


Here, we have examined the proposition that key components of pharmaceutical preparations for the treatment of sore throat which are routinely regarded antiseptics might have sodium channel- blocking, i.e. local anaesthetic-like effects.


We investigated the effects of hexylresorcinol, amylmetacresol and dichloro- benzylalcoholonvoltage-operatedneuronal(NaV1.2) sodium channels heterologously expressed in HEK 293 cells in vitro.

我们研究了间苯二酚、戊间甲酚和二氯苄醇对表达在 HEK293 细胞上的异源性电压门控神经元钠离子通道(NaV1.2)的影响。

Hexylresorcinol, amylmetacresol and dichloro-benzylalcohol reversibly blocked depolarisation-induced whole-cell sodium inward currents.


The half-maximum blocking concentrations (EC50) at−150 mV were 23.1, 53.6 and 661.6 µM, respectively.

- 150 毫伏时的半数阻滞浓度(EC50)分别为 23.153.6 661.6 微摩尔。

Block induced by hexylresorcinol and amylme- tacresol was increased at depolarised potentials and use-dependent during trains of depolarisations applied at high frequency (100 Hz) indicating that both drugs bind more tightly to inactivated conformations of the channel.


Estimates for the inactivated state affinity were 1.88 and 35 µM for hexylresorcinol and amylmetacresol, respectively.

间苯二酚和戊间甲酚与灭活构象的结合亲和力的估计值分别为 1.88 35 微摩尔


List of sample translations

Sample 1_life sciences_guidline for solubility of peptides  

Sample 2_Medical_Basics: Pathophysiology 

Sample 3_Medical Devices_Atherectomy system  

Sample 4_Medical:healthcare_patient report

Sample 6_Psychology_test